AKT inhibitor ( AKT protein kinase inhibitor )

Catalog No. M10037 CAS No. 1004990-28-6

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Product Name

AKT inhibitor
Note

Research use only, not for human use.
Brief Description

A broadly selective, potent, ATP-competitive Akt kinase inhibitor with IC50 of 0.5 nM(biochemical assay), and 0.31 nM (cell function assay).
Description

A broadly selective, potent, ATP-competitive Akt kinase inhibitor with IC50 of 0.5 nM(biochemical assay), and 0.31 nM (cell function assay); shows >900-fold selectivity over PKA; excellent PK profiles and effective in in vivo models of xenograft tumor.
Synonyms

AKT protein kinase inhibitor
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Akt
Recptor

Akt
Research Area

Cancer
Indication

——

CAS Number

1004990-28-6
Formula Weight

400.43
Molecular Formula

C20H22F2N6O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(NC[C@]1(N)CN(C2=C3C(NC=C3CC)=NC=N2)CC1)C4=CC=C(F)C=C4F
Chemical Name

Benzamide, N-[[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-pyrrolidinyl]methyl]-2,4-difluoro-

1. Freeman-Cook KD, et al. J Med Chem. 2010 Jun 24;53(12):4615-22.
2. Chen SF, et al. J Mol Model. 2013 Nov;19(11):5097-112.

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